STATUS OF SOME CARDIO-HEPATO-RENAL, OXIDATIVE STRESS, AND INFLAMMATORY BIOMARKERS AMONG COMMERCIAL FISHERMEN IN KIRIKIRI WATERSIDE, LAGOS, NIGERIA

Abstract

Fishing is an occupation that is involved in the cultivation, processing, preservation, storage, transportation, marketing or sale of fish and its products. This study was aimed on the status of some cardio-hepato-renal, oxidative stress and inflammatory biomarkers among commercial fishermen in Kirikiri waterside, Lagos Nigeria. Five milliliter of blood was collected via venipuncture technique from each of the sixty commercial fishermen selected for this study and categorized into three groups: experimental group one made up of thirty within the age bracket of 24 .and 37 years who are fishermen for less than 7 years, experimental group two made up of thirty commercial fishermen within age bracket of 24 and 37 years who are fishermen for 7-12 years and non-fishermen within the age bracket of 24 to 37 years who served as control group. The blood specimens were dispensed into lithium heparin anti-coagulated bottles respectively and spun at 2,500 revolution/minute with the obtained plasma used for the measurement of the following biomarkers: troponin-1 (immune turbidimetric method), creatineKinase-MB (immune inhibition method), alanine aminotransferase (colorimetric method), aspartate aminotransferase(colorimetric method), creatinine (Jaffe reaction method), urea (urease berthelot method), malondialdehyde (thiobarbituric acid method), glutathione peroxidase(ultra violet method), C-reactive protein (latex turbidimetry method) and interleukin-6 (elascience method),.The data obtained from these measurements were analyzed using SPSS 23.0 version as statistical package and the differences between the groups assessed using student “t” test which were considered significant at a p-value lesser than 0.05. The results in experimental group one fishermen revealed no statistically significant differences (p > 0.05) in the mean values of troponin-1, creatineKinase, alanine aminotransferase, aspartate aminotransferase, creatinine and urea, while C-reactive protein (p=0.03), interleukin-6 (p=0.03), malondialdehyde (p=0.02) and glutathione peroxidase (p=0.02) revealed significant elevations as compared to the control group. However, in the experimental group two fishermen, apart from troponin-1 (p=0.04), creatineKinase (p=0.04), C-reactive protein (p=0.02), interleukin-6 (p=0.02), malondialdehyde (p=0.01) and glutathione peroxidase (p=0.01) that were significantly elevated, the other measured biochemical parameters were not significantly altered (p>0.05) when compared to the control group. In conclusion, this study has found that fishermen within these studied categories may be at risk of developing cardio-inflammatory and oxidative stress biomarkers abnormalities. Routine check-up of these biomarkers is therefore recommended for commercial fishermen within these categories