IDENTIFICATION OF RHOPTRY PROTEINS (ROP5) VIRULENCE FACTORS OF MICROSPORIDIA AMONG APPARENTLY HEALTHY AND IMMUNOCOMPROMISED PATIENTS

Authors

  • Ubanwa, E. D. Department of Applied Biology and Biotechnology, Faculty of Applied National Science, Enugu state University of Science and Technology.
  • Omalu, I. C. J. Federal University of Technology Minna.
  • Njom, V. S. Enugu State University of Science and Technology.
  • Abah, O. M. National Examination Council

Keywords:

Rhoptry Proteins (Rop5), Virulence Factors, Microsporidia, Apparently Healthy and Immunocompromised Patients

Abstract

The rhoptries are key secretory organelles from apicomplexan parasites that contain proteins involved in invasion and modulation of the host cell. Many rhoptry proteins have been shown to be key players in apicomplexan and virulence. Rhoptry 5 protein (ROP5) have been identified as important virulence factor uses by microsporidia species to invade the host. This ROP5 varies from difference diseases conditions from 0.021 Optical density to 0.411 Optical density, the minimum cut off level at which microsporidia becomes virulence was 0.261 OD. The highest OD was among Mal/AIDS disease condition 0.328 OD and the least was from TB + patients 0.236 OD. Age was also a determinant factor of the virulence as highest ROP5 was from 0 - 14 years 0.411 OD and least was from 20 - 24 years 0.212 OD. Understanding the mechanism of this factor will help to improve the lives of immunocompromised individual.   

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Published

2022-08-19

How to Cite

Ubanwa, E. D., Omalu, I. C. J., Njom, V. S., & Abah, O. M. (2022). IDENTIFICATION OF RHOPTRY PROTEINS (ROP5) VIRULENCE FACTORS OF MICROSPORIDIA AMONG APPARENTLY HEALTHY AND IMMUNOCOMPROMISED PATIENTS. Irish International Journal of Engineering and Applied Sciences, 6(4). Retrieved from https://aspjournals.org/Journals/index.php/iijeas/article/view/105

Issue

Vol. 6 No. 4 (2022): July-August

Section

Articles