CONTEMPORARY CLINICAL TOOLS FOR ASSESSMENT, DIAGNOSIS AND MANAGEMENT OF ASTHMA

Abstract: Asthma is a chronic heterogeneous inflammatory disorder/syndrome of the airways that affects more than 300 Million people worldwide. Asthma often starts in childhood (Allergic Asthma phenotype).Co morbidities often trigger asthma exacerbations. It’s often difficult to diagnose asthma in young children. Objective tests of lung function aid in the diagnosis of asthma in children > six years of age. Asthma has phenotypes and endotypes.  Biomarkers Ex. Fractional excretion of Nitric Oxide aid in the diagnosis of severe asthma in children and adults. Management of Severe Asthma has undergone a revolution. Asthma is responsible for considerable global morbidity and health-care costs. Substantial progress was made against key outcomes such as hospital admissions with asthma and mortality in the 1990s and early 2000s, but little improvement has been observed in the past 10 years, despite escalating treatment costs.

TREATMENT AND PREVENTION OF ANTHRACYCLINE CARDIOTOXICITY: MOLECULAR DIAGNOSIS OF PRIMARY MEDIASTINAL B CELL LYMPHOMA

Abstract: Primary mediastinal B-cell lymphoma (PMBCL) is a relatively rare lymphoma subtype affecting mainly young adults. Its molecular signature and clinical features resemble classical Hodgkin lymphoma. The optimal chemotherapy for this lymphoma subtype has not been established. The addition of rituximab to anthracycline based chemotherapy improved response rates and survival. Many centers use R-CHOP as standard treatment, but the role of the intensified regimens and consolidation radiotherapy has to be clarified. Recent data coming from retrospective analyses and an ongoing prospective study addressing the problem of consolidation radiotherapy will help to better identify risk groups and apply risk-adapted and effective treatment strategies. The latest research has helped to understand molecular mechanisms of PMBCL pathogenesis and indicated targets of directed therapy for the future. 

ASSESSMENT OF CONVENTIONAL FUNGICIDES AND BIOCHEMICAL EXTRACTS AGAINST TOMATO EARLY BLIGHT DISEASE

Abstract: Fungicidal activity of nine selected conventional fungicides, identified five plant oils and their combined effect against A. solani, the causal pathogen of early blight on tomato. GC-MS analysis of the tested oils indicated that terpene hydrocarbons (97%) with cinnamaldehyde as the major compound; sulfur compounds; fatty acids and organo-sulfurcontaining compounds were the main components in cinnamon, garlic, mustard and onion oils, respectively. In vitro, Speedcide® (difenoconazole) and Cabrioduo® (Dimethomorph + Pyraclostrobin) were the most effective against the A. solani fungus with EC50 values of 94.6 and 88.6 ppm respectively. Toledo® (Tebuconzole) achieved EC50 value of 631.2 ppm. Roxyl-M® was significantly more effective than Roxyl–plus® or Remik®. Speedcide® alone or mixed with mandipropamid or azoxystrobin in Revus-Top® or Cruze® were the lowest effective in vitro. Garlic and mustard oils were more effective in liquid media than solid one. Cinnamon, onion, garlic and bitter almond oils caused moderate fungi-toxicity against early blight pathogen and could be implemented in the IPM program. Lower EC50 values were obtained in case of combinations of fungicides with oils than separate treatments.  Effect of the active conventional fungicides and plant oils on disease indices, relative disease control, chlorophyll content, sugar contents and poly phenol oxidase in tomato plants was also studied. 

PERSPECTIVES ON INNOVATION AND TECHNOLOGY TRANSFER IMPACT ON THE PERFORMANCE OF WOMEN-OWNED MICRO SMALL MEDIUM ENTERPRISES (MSMES)

Abstract The main objective of the study was to establish the impact of technology transfer on the performance of women-owned MSMEs in Kisii County, Kenya. To achieve this objective a sample size of 288 enterprises was selected based on Israel, G. D.  (1992) sample size formula. A descriptive survey was employed to gather information. Primary data was collected from the indicated target women enterprises using questionnaires. The correlation analysis results revealed that technology transfer had a positive significant association with the performance of women-owned MSMEs in Kisii County, Kenya. The regression analysis results revealed that technology transfer significantly accounted for the positive variability in the performance of women-owned MSMEs in Kisii County, Kenya. The major setback of this study was the exclusive use of questionnaires to collect data. Future studies should consider employing interview guides and secondary information in order to come up with objective reliable findings on the impact of business development services on the performance of women-owned MSMEs. Future studies can also consider determining the moderating effect of the external business environment on the relationship between the business development services and organizational performance in women-owned or youth owned MSMEs.

SYNTHESIS OF EASTERN AND WESTERN CULTURE IN CONTEMPORARY APPROACH: AN ANALYSIS OF RAZA BUKHARI’S CONCEPTUAL PAINTINGS

Abstract:Painting serves as a medium to satisfy artist’s sense of perception and provides space to portray his own imagination. The researcher here reveals an attempt by Raza Bukhari to capture the fusion of two culture’s, western cartoon character fitting in the eastern Persian miniature, or somewhere western subject adorned with Persian motif, creating contemporary approach in the traditional manner of miniature painting, which helps him to produce the visual copy of his expression and display his inner most thoughts. Observing two A tastes on one canvas brings the observer to discover the hidden messages of the visual, to effectuate the need this paper is going to focus the imagery and symbolism used by Raza Bukhari to express the human psychology of adopting foreign culture, and fitting themselves in that. His masterly skills of using opaque colour for creating a painting and the use of cat hair brush, accompanied with other techniques further modifies and helps in delivering the essence of painting.

MOLECULAR INSIGHTS INTO THE GENETIC AND HAPLOTYPE DIVERSITY AMONG FOUR POPULATIONS OF LOCAL ORNAMENTAL PALO FISH (BETTA SP.: OSPHRONEMIDAE)

Abstract: Cytochrome b gene mitochondrial DNA was used to study the Palo fish from Bukit Rangkak tributary, Harau Valley, West Sumatra. The study aimed to determine the taxonomy of Palo fish, which morphological suspected as the Betta group. Phylogenetic analysis was used to solve the relationship of Palo fish with other species of the Betta. The alignment of the DNA sequences was carried out with Clustal X version 2 and analysis of phylogenetic tree using MEGA 6 software program. Based on the analysis of the cytochrome b gene sequence (1047 bp), it is known that the genetic differences of Palo fish from two tributaries of Bukit Rangkak river is 0.0% and with other Betta fish ranges from 13.0-35.5%. The phylogenetic tree has shown that Palo fish has a close genetic relationship with the Betta picta (13.0%). The result showed that Palo fish is at the different species in the genus of Betta and proposed as a new species.

APPLICABILITY OF THE WHO MATERNAL NEAR MISS TOOL IN SUBSAHARAN AFRICA: AN ANALYSIS OF 50 CASES

Abstract : This study was conducted to analyse in detail about the Maternal Near Miss mortality (MNMM). The incidence of maternal near miss mortality, the adverse events leading to MNMM, sociodemographic factors, disorders underlying, patterns of near miss mortality and facilities and skills needed to handle this situation are studied in a local context.This is an open study conducted in KGH during the period of april 2013 to November 2013. Materials and methods: maternal near miss cases which met the comprehensive criteria of WHO were included. All women with severe life threatening conditions who fulfilled the WHO criteria were identified and flagged. Their course of hospital stay was followed closely. A total of 50 cases were included. Each case was documented with respect to the adverse event, the disorder and organ dysfunction. Those who survived were included in this study as MNMM. Those who did not survive were not included in this study. All the data needed were collected from hospital records analyzed and master charted to statistical data. Results: The MNMM incidence ratio in this study is 0.8 per 1000 live births. This is comparable to High income developed countries where it is between 0.6 and 1%. Hypertensive disorders and Hemorrhage and are the leading causes of near miss situations. The Mortality Index is low at 0.05, it reflects good quality of care. The causes of Near Miss reflect the causes of maternal death. Near miss analysis is worth presenting in national indices as a surrogate for maternal death.    

EFFECTS OF PARENTING STYLE ON CHILDREN ACADEMIC ACHIEVEMENT: A CASE STUDY OF PRIMARY SCHOOLS IN AWKA SOUTH LOCAL GOVERNMENT EDUCATION AUTHORITY

Abstract                                                   
This study was carried out to investigate the influence of parenting styles on the academic achievement of pupils in Mathematics in Awka South Local Government Education Authority of Anambra State. The study adopted an ex-post facto research design. Two research questions guided the study. The population of the study consisted of 2,377 Primary five pupils in the 45 public primary schools in Awka South Local Government Education Authority. The sample comprised of 424 Primary five pupils selected using multi-stage sampling. Data were collected using a researcher structured questionnaire titled “Questionnaire on Parenting Styles (QPS)”.The 2018/2019 mathematics achievement scores of students in each sampled schools were also used. The QPS was validated by three experts. The reliability of the instrument was determined using Cronbach Alpha which yielded an overall co-efficient of 0.83. Mean was used to answer the research questions while standard deviation was used to check the closeness of the respondents’ responses to the mean. The findings revealed that parents use of authoritative parenting style mostly influence academic achievement of excellence in pupils in mathematics; Parents use of authoritarian and permissive parenting styles mostly influence academic achievement of good in pupils in mathematics; and parents use of uninvolved parenting style mostly led to failure of pupils in mathematics. Based on these findings, the researcher recommended among others that the State government through the Ministry of Education should organize guidance and counseling programmes in the communities to sensitize, educate and empower parents on various parenting styles and their influence on academic achievement of pupils; and Teachers should make efforts to know their pupils’ parents and families so as to know the goals they have set for their children