Developing nations are plagued by epileptic power generation and supply to their economy, particularly Africans. Compounding this problem is the enormous particulate and liquid waste generation from the exploitation and exploration of fossilized fuel production that pollutes the environment. However, value added products such as biodiesel synthesized from waste oils could be valorized into other products and generate bioenergy. In this study, a solid catalyst produced from two waste materials namely; waste industrial brine and coal fly ash, was utilized to convert animal fat oil (AFO) to biodiesel via transesterification in a sustainable manner. The techno-economic assessment of the waste-derived catalyst (HSOD) in the transesterificationof AFO to biodiesel was studied and compared with that of a homogeneous acidcatalyst (H2SO4) via the application of a simulation tool (ASPEN software). The techno-economic assessment indicates a promising high rate of return on investment for biodiesel production in both scenarios, but the use of waste-derived HSOD was foundto be more economical in comparison with the use of H2SO4 in the transesterification of AFO to biodiesel. The use of waste-derived solid HSOD catalyst isalsofound to be tolerant to high free fatty acid (FFA) contentof AFO, hence; HSOD is found ideal for use in the biodiesel production process. More importantly, by by-passing the esterification unit, which is a process in the case of H2SO4, the production cost of biodiesel from AFO could be reduced with the use of the waste-derived HSOD catalyst. The study provided a significant insight into emerging bioenergy-mix with fossil energy production which is fast developing in South Africa in particular and Sub-Saharan Africa in generaldue to the sustainable feedstock availability in South Africa and Nigeria